1 00:00:05,910 --> 00:00:03,270 hello in the next minute let me tell you 2 00:00:07,030 --> 00:00:05,920 how rna could have played a pivotal role 3 00:00:09,910 --> 00:00:07,040 in the emergence of 4 00:00:11,190 --> 00:00:09,920 organized cellular life from inanimate 5 00:00:13,270 --> 00:00:11,200 matter 6 00:00:15,430 --> 00:00:13,280 i am creating experimental models for 7 00:00:17,349 --> 00:00:15,440 some of the major chemical transitions 8 00:00:19,349 --> 00:00:17,359 rna had to go through from the 9 00:00:22,150 --> 00:00:19,359 simplicity of its building blocks 10 00:00:23,990 --> 00:00:22,160 to its complex catalytic functions i 11 00:00:27,589 --> 00:00:24,000 will discuss how we identified 12 00:00:30,070 --> 00:00:27,599 rna enzymes or ribozymes that catalyze 13 00:00:32,389 --> 00:00:30,080 the assembly of probiotically plausible 14 00:00:34,630 --> 00:00:32,399 activated rna substrates 15 00:00:36,549 --> 00:00:34,640 i will also show you how such activated 16 00:00:37,830 --> 00:00:36,559 substrates could have been produced on 17 00:00:40,549 --> 00:00:37,840 early earth and how 18 00:00:42,069 --> 00:00:40,559 ribozymes that use these substrates 19 00:00:43,510 --> 00:00:42,079 could have functioned under these 20 00:00:46,069 --> 00:00:43,520 probiotic activation 21 00:00:47,190 --> 00:00:46,079 conditions finally i will show you how 22 00:00:50,069 --> 00:00:47,200 we constituted 23 00:00:52,150 --> 00:00:50,079 rna catalyzed rna assembly within 24 00:00:53,029 --> 00:00:52,160 prebiotically relevant fatty acid 25 00:00:54,869 --> 00:00:53,039 protocells 26 00:00:56,630 --> 00:00:54,879 which will hopefully pave the way for 27 00:00:59,029 --> 00:00:56,640 the spontaneous emergence 28 00:01:00,229 --> 00:00:59,039 of darwinian evolution in non-living